DespiseDESPISE, .verb intransitive1. To contemn; to scorn; to disdain; to have the lowest opinion of.Fools despise wisdom and instruction. [[Proverbs 1#7|Proverbs 1:7]].Else he will hold to the one, and despise the other. [[Matthew 6#24|Matthew 6:24]].2. To abhor.